Hello đź‘‹ I'm Shweta
I am currently working as a postdoctoral researcher and bioinformatician at Amsterdam UMC, specializing in integrating multi-omic data to better understand cancer biology and advance precision diagnostics. My current research focuses on leveraging liquid biopsies (such as blood plasma) and CRISPR-based biomarker detection to identify disease-specific molecular signatures. I work in close collaboration with clinical teams across leading Dutch research institutes and hospitals. My goal is to uncover clinically actionable biomarkers hidden within complex datasets and translate them into simple, accessible diagnostic tools—bringing cutting-edge science to patients around the world.
Current Affiliation
Post-Doc/Bioinformatician, Pathology
Amsterdam UMC, Netherlands
(Oct 2024 – Present)
About Amsterdam UMC
Mission: Amsterdam UMC is a leading academic medical center dedicated to patient care, scientific research, and education. It strives to improve healthcare through innovation and collaboration.
Key Areas: Complex patient care, innovative research across oncology, neuroscience, and infectious diseases, plus training future healthcare professionals.
Size & Impact: One of the largest Dutch university medical centers, formed by merging AMC & VUmc, driving regional and national healthcare advances.
Research Profile
What is multi-omics?
DNA makes RNA, and RNA makes proteins—the workhorses of the cell. Looking at one layer rarely tells the full story. Multi-omics stitches layers together to see how changes propagate across the system.
Why it matters
- Reveals biology that single-layer assays miss.
- Finds biomarkers that contribute to diagnosis and prognosis.
- Supports smarter therapy selection and de-escalation.
Where I apply it
- Pediatric brain tumors: medulloblastoma, ependymoma, HGG.
- Other solid tumors, including breast cancer.
- High-dimensional integration: proteome, glycome, DNA-methylome, transcriptome, phospho-proteome.
Bridging access
Multi-omics is powerful, but not every lab can afford it for all samples. Hence, I aim to propose simpler, detectable biomarkers that deliver value in resource-limited settings.
Liquid biopsies
I focus on plasma-based assays as a less invasive way to diagnose and monitor diseases. My current work centers on extracellular vesicles—tiny sacs released by cells that carry molecular cargo from the tumor and surrounding cells.
Goal
Translate complex data into reliable, actionable biomarkers and deploy them through simple, scalable diagnostics that help patients sooner.
Collaboration
Progress is a team sport. I collaborate closely with clinicians and researchers in the Netherlands and beyond, and I’m especially keen to build bridges with teams in India to make research more accessible, applicable, and impactful for patients and families.